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COVID-19 is the most prominent and rapidly evolving public health concern in the world currently. The gastrointestinal manifestations of COVID-19 are increasingly being recognized. SARS-CoV-2 infection has been associated with the occurrence of nausea, vomiting, and diarrhea. SARS-CoV-2 has also been causing pancreatic and hepatic injury. Emerging data have shown that COVID-19 patients continue to shed the virus into their stools, even when patients test negative for COVID-19 in pulmonary secretions. However, the epidemiology, pathogenesis, and treatment of SARS-CoV-2-related gastrointestinal manifestations are poorly understood. The pandemic has also had a significant impact on gastroenterologists, endoscopists, and other ancillary staff. Moreover, in the past, systematic respiratory virus syndrome (SARS) was shown to be transmitted by endoscopes, which is a big concern with COVID-19, as it shares many pathological features with SARS. The deferral of elective endoscopic procedures has negatively affected gastroenterologists. This Special Issue focuses on the current situation of this pandemic. It aims to provide insight into the gastrointestinal manifestations of COVID-19 and its effects on endoscopic procedures. I believe that this issue will be beneficial not only for gastroenterologists but also other healthcare workers around the world to recognize the often-ignored clinical gastrointestinal manifestations of COVID-19.

Medicine --- COVID-19 --- liver --- non-alcoholic steatohepatitis --- transient elastography --- mortality --- liver disease --- clinical manifestations --- SARS-CoV-2 --- gastroenterology --- hepatology --- endoscopy --- delivery of healthcare --- acute mesenteric ischemia --- thromboemboembolism --- endothelitis --- cytokines --- hypercoagulability --- inflammatory bowel disease --- gastrointestinal manifestations --- abdominal pain --- dyspnea --- clinical course --- upper gastrointestinal bleeding --- pandemic --- outcomes --- anxiety --- depression --- medication adherence --- severity of COVID-19 --- hospitalized patients --- risk factors --- SARS-CoV-2 infection --- gut dysbiosis --- microbiota --- gastrointestinal disorders --- intestinal inflammation --- ACE2 dysregulation --- gut microbiota --- enteric infection

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Sarcopenia represents the decline in skeletal muscle mass and function with age, characterized by the muscle fiber's quality, strength, muscle endurance, and metabolic ability decreasing, as well as the fat and connective tissue growing.Reduction of muscle strength with aging leads to loss of functional capacity, causing disability, mortality, and other adverse health outcomes. Because of the increase of the proportion of elderly in the population, sarcopenia-related morbidity will become an increasing area of health care resource utilization.Diagnostic screening consists of individuation of body composition, assessed by DEXA, anthropometry, bioelectrical impedance, MRI, or CT scan. Management is possible with resistance training exercise and vibration therapy, nutritional supplements, and pharmacological treatment.The book includes articles from different nationalities, treating the experimental and medical applications of sarcopenia. The consequences of sarcopenia in frailty are treated in relation to other associated pathologies or lesions, as femoral neck fractures and hepatocellular carcinoma.

muscle-mass --- sleep efficiency --- sleep duration --- insomnia --- sarcopenia --- quality of life --- osteoporosis --- postmenopausal women --- sedentary behaviour --- aged --- exercise --- motivation --- hepatoma --- myokine --- decorin --- walking distance --- survival --- muscle strength --- resistance training --- randomized controlled trial --- nutritional status --- nutritional screening tools --- hospitalized older patients --- resistance exercise training --- muscle regulatory factors --- deconditioning --- skeletal muscle --- elderly --- hypertrophy --- multimorbidity --- polypathological patients --- frailty --- oxidative stress --- telomere length --- apoptosis --- spirometry --- urea --- fatigue --- respiratory system --- skeletal muscles --- lipids --- transaminases --- falls --- resistance exercise --- vibration --- electrical stimulation --- hip fracture --- diagnosis --- treatment --- prevention --- dual-energy X-ray absorptiometry --- bisphosphonate --- β-hydroxy-β-methylbutyrate --- exercise intervention --- fall risk --- balance --- anxiety --- depression --- sleep quality --- type 2 diabetes --- physical activity --- muscle mass --- protein intake --- accelerometer --- aerobic exercise training --- mitochondria --- endurance --- fractures --- ageing fractures --- complications --- recovery --- rehabilitation --- nutritional supplements --- physical therapy --- cognition --- brain-body cross-talk --- older persons --- prevalence --- physical functional performance --- epidemiologic studies --- aging --- panoramic ultrasound --- echogenicity --- specific force --- isokinetic dynamometry --- muscle quality --- strength --- older adults --- diagnostic criteria --- clinical